{"metadata":{"accession":"PF07161","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009830","hierarchy":null,"name":{"name":"LppX_LprAFG lipoprotein","short":"LppX_LprAFG"},"description":[{"text":"<p>This entry consists of several lipoproteins mainly from Mycobacterium species, collectively known as the LppX_ LprAFG family. Proteins in this entry include LprG, LppX,  LprF and lprA [[cite:PUB00020730],[cite:PUB00020731],[cite:PUB00020732],[cite:PUB00039808],[cite:PUB00020734],[cite:PUB00076900]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00039808":{"PMID":16541102,"ISBN":null,"volume":"25","issue":"7","year":2006,"title":"LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis.","URL":null,"raw_pages":"1436-44","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Sulzenbacher G","Canaan S","Bordat Y","Neyrolles O","Stadthagen G","Roig-Zamboni V","Rauzier J","Maurin D","Laval F","Daffe M","Cambillau C","Gicquel B","Bourne Y","Jackson M."],"DOI_URL":"http://dx.doi.org/10.1038/sj.emboj.7601048"},"PUB00020730":{"PMID":9387238,"ISBN":null,"volume":"143 ( Pt 11)","issue":null,"year":1997,"title":"A novel 27 kDa lipoprotein antigen from Mycobacterium bovis.","URL":null,"raw_pages":"3599-605","medline_journal":"Microbiology","ISO_journal":"Microbiology (Reading, Engl.)","authors":["Bigi F","Espitia C","Alito A","Zumarraga M","Romano MI","Cravero S","Cataldi A."],"DOI_URL":null},"PUB00020734":{"PMID":12581360,"ISBN":null,"volume":"47","issue":"4","year":2003,"title":"Interaction of the sensor module of Mycobacterium tuberculosis H37Rv KdpD with members of the Lpr family.","URL":null,"raw_pages":"1075-89","medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Steyn AJ","Joseph J","Bloom BR."],"DOI_URL":"http://dx.doi.org/10.1046/j.1365-2958.2003.03356.x"},"PUB00076900":{"PMID":16785538,"ISBN":null,"volume":"177","issue":"1","year":2006,"title":"Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function.","URL":null,"raw_pages":"422-9","medline_journal":"J Immunol","ISO_journal":"J. Immunol.","authors":["Pecora ND","Gehring AJ","Canaday DH","Boom WH","Harding CV."],"DOI_URL":"http://dx.doi.org/10.4049/jimmunol.177.1.422"},"PUB00020731":{"PMID":14998516,"ISBN":null,"volume":"6","issue":"2","year":2004,"title":"The knockout of the lprG-Rv1410 operon produces strong attenuation of Mycobacterium tuberculosis.","URL":null,"raw_pages":"182-7","medline_journal":"Microbes Infect","ISO_journal":"Microbes Infect.","authors":["Bigi F","Gioffre A","Klepp L","Santangelo MP","Alito A","Caimi K","Meikle V","Zumarraga M","Taboga O","Romano MI","Cataldi A."],"DOI_URL":"http://dx.doi.org/10.1016/j.micinf.2003.10.010"},"PUB00020732":{"PMID":15294983,"ISBN":null,"volume":"173","issue":"4","year":2004,"title":"Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing.","URL":null,"raw_pages":"2660-8","medline_journal":"J Immunol","ISO_journal":"J. Immunol.","authors":["Gehring AJ","Dobos KM","Belisle JT","Harding CV","Boom WH."],"DOI_URL":"http://www.jimmunol.org/cgi/reprint/173/4/2660"}},"set_info":{"accession":"CL0048","name":"LolA_LolB"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":1679,"pathways":0,"proteins":1675,"proteomes":1240,"sets":1,"structural_models":{"alphafold":1053},"structures":6,"taxa":1591},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":12,"alignment:full":731},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4zra","name":"CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LPRG BINDING TO TRIACYLGLYCERIDE"}}}