{"metadata":{"accession":"PF07160","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009829","hierarchy":null,"name":{"name":"Spindle and kinetochore-associated protein 1","short":"SKA1"},"description":[{"text":"<p>Spindle and kinetochore-associated protein 1 (SKA1) is a component of the SKA1 complex (consists of Ska1, Ska2, and Ska3/Rama1), a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation [[cite:PUB00061771]]. It is required for  timely anaphase onset during mitosis, when chromosomes undergo  bipolar attachment on spindle microtubules leading to silencing of  the spindle checkpoint [[cite:PUB00061805]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00061771":{"PMID":17093495,"ISBN":null,"volume":"25","issue":"23","year":2006,"title":"Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2.","URL":null,"raw_pages":"5504-15","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Hanisch A","Sillje HH","Nigg EA."],"DOI_URL":"http://dx.doi.org/10.1038/sj.emboj.7601426"},"PUB00077600":{"PMID":24413531,"ISBN":null,"volume":"5","issue":null,"year":2014,"title":"Structural basis for microtubule recognition by the human kinetochore Ska complex.","URL":null,"raw_pages":"2964","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Abad MA","Medina B","Santamaria A","Zou J","Plasberg-Hill C","Madhumalar A","Jayachandran U","Redli PM","Rappsilber J","Nigg EA","Jeyaprakash AA."],"DOI_URL":"http://dx.doi.org/10.1038/ncomms3964"},"PUB00061805":{"PMID":22483620,"ISBN":null,"volume":"46","issue":"3","year":2012,"title":"Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface.","URL":null,"raw_pages":"274-86","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Jeyaprakash AA","Santamaria A","Jayachandran U","Chan YW","Benda C","Nigg EA","Conti E."],"DOI_URL":"http://dx.doi.org/10.1016/j.molcel.2012.03.005"}},"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":44,"interactions":0,"matches":1976,"pathways":0,"proteins":1873,"proteomes":1423,"sets":1,"structural_models":{"alphafold":1644},"structures":4,"taxa":4522},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":30,"alignment:full":1500},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}