{"metadata":{"accession":"PF07159","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009828","hierarchy":null,"name":{"name":"CYRIA/CYRIB Rac1 binding domain","short":"CYRIA-B_Rac1-bd"},"description":[{"text":"<p>This domain has been annotated as Rac1-binding domain [[cite:PUB00093956],[cite:PUB00093955]]. It can be found in human CYRIA/CYRIB and at the N terminus of CYFIP1/2 [[cite:PUB00093957]]. CYFIP proteins are known RAC1 effectors that stimulate actin polymerization [[cite:PUB00093957]]. In mice, CYRIB (also known as CYRI or FAM49B) negatively regulates RAC1-driven cytoskeletal remodelling and plays a role in restricting infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes [[cite:PUB00093957]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00093957":{"PMID":31285585,"ISBN":null,"volume":"4","issue":"9","year":2019,"title":"CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection.","URL":null,"raw_pages":"1516-1531","medline_journal":"Nat Microbiol","ISO_journal":"Nat Microbiol","authors":["Yuki KE","Marei H","Fiskin E","Eva MM","Gopal AA","Schwartzentruber JA","Majewski J","Cellier M","Mandl JN","Vidal SM","Malo D","Dikic I."],"DOI_URL":null},"PUB00093956":{"PMID":31413787,"ISBN":null,"volume":"12","issue":"1","year":2019,"title":"CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors.","URL":null,"raw_pages":"112-118","medline_journal":"Commun Integr Biol","ISO_journal":"Commun Integr Biol","authors":["Whitelaw JA","Lilla S","Paul NR","Fort L","Zanivan S","Machesky LM."],"DOI_URL":null},"PUB00093955":{"PMID":30250061,"ISBN":null,"volume":"20","issue":"10","year":2018,"title":"Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.","URL":null,"raw_pages":"1159-1171","medline_journal":"Nat Cell Biol","ISO_journal":"Nat. Cell Biol.","authors":["Fort L","Batista JM","Thomason PA","Spence HJ","Whitelaw JA","Tweedy L","Greaves J","Martin KJ","Anderson KI","Brown P","Lilla S","Neilson MP","Tafelmeyer P","Zanivan S","Ismail S","Bryant DM","Tomkinson NCO","Chamberlain LH","Mastick GS","Insall RH","Machesky LM."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":71,"interactions":0,"matches":8217,"pathways":0,"proteins":8041,"proteomes":1782,"sets":0,"structural_models":{"alphafold":6654},"structures":9,"taxa":5573},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":30,"alignment:full":6594},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}