{"metadata":{"accession":"PF07139","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009816","hierarchy":null,"name":{"name":"Spermatogenesis-associated serine-rich protein 2-like","short":"SPATS2-like"},"description":[{"text":"<p>This family includes spermatogenesis-associated serine-rich protein 2 (SPATS2) and SPATS2-like proteins from mammals. SPATS2 is involved in  spermatogenesis and likely to be a cytoplasmic RNA-binding protein [[cite:PUB00101497],[cite:PUB00101498]].  SPATS2 is highly expressed in hepatocellular carcinoma (HCC) and may function as an oncogene. It constitutes a novel diagnostic prognostic  marker in liver cancer and a potential therapeutic target for the treatment of HCC [[cite:PUB00101499]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00101497":{"PMID":33037180,"ISBN":null,"volume":"11","issue":"10","year":2020,"title":"SPATS2, negatively regulated by miR-145-5p, promotes hepatocellular carcinoma progression through regulating cell cycle.","URL":null,"raw_pages":"837","medline_journal":"Cell Death Dis","ISO_journal":"Cell Death Dis","authors":["Dong G","Zhang S","Shen S","Sun L","Wang X","Wang H","Wu J","Liu T","Wang C","Wang H","Lu T","Rao B","Ren Z."],"DOI_URL":null},"PUB00101498":{"PMID":35077478,"ISBN":null,"volume":"17","issue":"1","year":2022,"title":"SPATS2 is positively activated by long noncoding RNA SNHG5 via regulating DNMT3a expression to promote hepatocellular carcinoma progression.","URL":null,"raw_pages":"e0262262","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Yan J","Huang QY","Huang YJ","Wang CS","Liu PX."],"DOI_URL":null},"PUB00101499":{"PMID":32118724,"ISBN":null,"volume":"99","issue":"9","year":2020,"title":"Comprehensive evaluation of SPATS2 expression and its prognostic potential in liver cancer.","URL":null,"raw_pages":"e19230","medline_journal":"Medicine (Baltimore)","ISO_journal":"Medicine (Baltimore)","authors":["Xing J","Tian Y","Ji W","Wang X."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":2097,"pathways":0,"proteins":1891,"proteomes":857,"sets":0,"structural_models":{"alphafold":1669},"structures":0,"taxa":2752},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":17,"alignment:full":1773},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}