{"metadata":{"accession":"PF07125","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009808","hierarchy":null,"name":{"name":"Protein of unknown function (DUF1378)","short":"DUF1378"},"description":[{"text":"<p>This family consists of hypothetical bacterial and phage proteins of around 59 residues in length. Bacterial members of this family seem to be specific to Enterobacteria. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids [[cite:PUB00070793]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00070793":{"PMID":21348639,"ISBN":null,"volume":"15","issue":"7-8","year":2011,"title":"Ab initio modeling led annotation suggests nucleic acid binding function for many DUFs.","URL":null,"raw_pages":"431-8","medline_journal":"OMICS","ISO_journal":"OMICS","authors":["Rigden DJ."],"DOI_URL":"http://dx.doi.org/10.1089/omi.2010.0122"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":50,"pathways":0,"proteins":50,"proteomes":36,"sets":0,"structural_models":{"alphafold":20},"structures":0,"taxa":105},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":36},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}