{"metadata":{"accession":"PF07100","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009794","hierarchy":null,"name":{"name":"Anabaena sensory rhodopsin transducer","short":"ASRT"},"description":[{"text":"<p>The family of bacterial Anabaena sensory rhodopsin transducers are likely to bind sugars or related metabolites. The entire protein is comprised of a single globular domain with an eight-stranded beta-sandwich fold. There are a few characteristics which define this beta-sandwich fold as being distinct from other so-named folds, and these are: 1) a well conserved tryptophan, usually following a polar residue, present at the start of the first strand; this tryptophan appears to be central to a hydrophobic interaction required to hold the two beta-sheets of the sandwich together, and 2) a nearly absolutely conserved asparagine located at the end of the second beta-strand, that hydrogen bonds with the backbone carbonyls of the residues 2 and 4 positions downstream from it, thereby stabilising the characteristic tight turn between strands 2 and 3 of the structure.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100872":{"PMID":12622809,"ISBN":null,"volume":"47","issue":"6","year":2003,"title":"Demonstration of a sensory rhodopsin in eubacteria.","URL":null,"raw_pages":"1513-22","medline_journal":"Mol Microbiol","ISO_journal":"Mol Microbiol","authors":["Jung KH","Trivedi VD","Spudich JL."],"DOI_URL":null},"PUB00100873":{"PMID":19682383,"ISBN":null,"volume":"4","issue":null,"year":2009,"title":"The Anabaena sensory rhodopsin transducer defines a novel superfamily of prokaryotic small-molecule binding domains.","URL":null,"raw_pages":"25; discussion 25","medline_journal":"Biol Direct","ISO_journal":"Biol Direct","authors":["De Souza RF","Iyer LM","Aravind L."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":833,"pathways":0,"proteins":831,"proteomes":700,"sets":0,"structural_models":{"alphafold":520},"structures":5,"taxa":1314},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":27,"alignment:full":421},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2iia","name":"Anabaena sensory rhodopsin transducer"}}}