{"metadata":{"accession":"PF07063","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009770","hierarchy":null,"name":{"name":"2-oxoadipate dioxygenase/decarboxylase","short":"HGLS"},"description":[{"text":"<p>This entry represents a group of bacterial, fungal and plant sequences, including 2-oxoadipate dioxygenase/decarboxylase (referred to as HGLS and YdcJ) from Escherichia coli. YdcJ, which is involved in D-lysine metabolism, catalyses a successive decarboxylation and intramolecular hydroxylation of 2-oxoadipate forming  2-hydroxyglutarate in a Fe(II) and oxygen-dependent manner. Members of this protein family are thought to belong to the the vicinal oxygen chelate (VOC) superfamily [[cite:PUB00102155],[cite:PUB00102156]]. The structure has been solved (PDB:3iuz, PDB:6w1g).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00102155":{"PMID":31064836,"ISBN":null,"volume":"10","issue":"3","year":2019,"title":"Massively Parallel Fitness Profiling Reveals Multiple Novel Enzymes in Pseudomonas putida Lysine Metabolism. ","URL":null,"raw_pages":"e02577-18","medline_journal":"mBio","ISO_journal":"mBio","authors":["Thompson MG","Blake-Hedges JM","Cruz-Morales P","Barajas JF","Curran SC","Eiben CB","Harris NC","Benites VT","Gin JW","Sharpless WA","Twigg FF","Skyrud W","Krishna RN","Pereira JH","Baidoo EEK","Petzold CJ","Adams PD","Arkin AP","Deutschbauer AM","Keasling JD."],"DOI_URL":null},"PUB00102156":{"PMID":32523014,"ISBN":null,"volume":"11","issue":"1","year":2020,"title":"An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism.","URL":null,"raw_pages":"2931","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Thompson MG","Blake-Hedges JM","Pereira JH","Hangasky JA","Belcher MS","Moore WM","Barajas JF","Cruz-Morales P","Washington LJ","Haushalter RW","Eiben CB","Liu Y","Skyrud W","Benites VT","Barnum TP","Baidoo EEK","Scheller HV","Marletta MA","Shih PM","Adams PD","Keasling JD."],"DOI_URL":null}},"set_info":{"accession":"CL0104","name":"Glyoxalase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":39,"interactions":0,"matches":5475,"pathways":0,"proteins":5110,"proteomes":4514,"sets":1,"structural_models":{"alphafold":3348},"structures":6,"taxa":7095},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":349,"alignment:full":2510},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6w1g","name":"Crystal structure of the hydroxyglutarate synthase from Pseudomonas putida"}}}