{"metadata":{"accession":"PF07011","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009741","hierarchy":null,"name":{"name":"Early Flowering 4 domain","short":"Elf4"},"description":[{"text":"<p>This domain forms an alpha-helical homodimer in ELF4 proteins. Protein EARLY FLOWERING 4 (Elf4) is a component of the central CCA1/LHY-TOC1 feedback loop in the circadian clock that promotes clock accuracy and is required for sustained rhythms in the absence of daily light/dark cycles [[cite:PUB00084336],[cite:PUB00084337]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00084337":{"PMID":20357892,"ISBN":null,"volume":"3","issue":"5","year":2009,"title":"Integrating ELF4 into the circadian system through combined structural and functional studies.","URL":null,"raw_pages":"350-66","medline_journal":"HFSP J","ISO_journal":"HFSP J","authors":["Kolmos E","Nowak M","Werner M","Fischer K","Schwarz G","Mathews S","Schoof H","Nagy F","Bujnicki JM","Davis SJ."],"DOI_URL":"http://dx.doi.org/10.2976/1.3218766"},"PUB00084336":{"PMID":12214234,"ISBN":null,"volume":"419","issue":"6902","year":2002,"title":"The ELF4 gene controls circadian rhythms and flowering time in Arabidopsis thaliana.","URL":null,"raw_pages":"74-7","medline_journal":"Nature","ISO_journal":"Nature","authors":["Doyle MR","Davis SJ","Bastow RM","McWatters HG","Kozma-Bognar L","Nagy F","Millar AJ","Amasino RM."],"DOI_URL":"http://dx.doi.org/10.1038/nature00954"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":41,"interactions":0,"matches":2314,"pathways":0,"proteins":2312,"proteomes":403,"sets":0,"structural_models":{"alphafold":1854},"structures":0,"taxa":1138},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":21,"alignment:full":1439},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}