This entry describes a domain of unkown function found generally at the N-terminal of YubA and YubB in enterobacteriaceae. This domain is mostly found in Escherichia coli, Salmonella typhimurium and Shigella species. YubA and YubB have not been fully functionally characterised. YubB was identified as undecaprenyl diphosphate phosphatase (UPPP) due to its association with cell wall synthesis and bacitracin resistance when disrupted. YubA was inferred to be a transporter, possibly related to cell wall synthesis, based on its predicted membrane protein structure and its genomic association with the UPPP gene. These experiments were done using transposon mutagenesis [[cite:PUB00160281]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00160281":{"PMID":28248504,"ISBN":null,"volume":"60","issue":"6","year":2017,"title":"Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci.","URL":null,"raw_pages":"2425-2438","medline_journal":"J Med Chem","ISO_journal":"J Med Chem","authors":["Mohammad H","Younis W","Chen L","Peters CE","Pogliano J","Pogliano K","Cooper B","Zhang J","Mayhoub A","Oldfield E","Cushman M","Seleem MN."],"DOI_URL":"https://doi.org/10.1021/acs.jmedchem.6b01780"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":175,"pathways":0,"proteins":175,"proteomes":119,"sets":0,"structural_models":{"alphafold":118},"structures":1,"taxa":215},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":15,"alignment:full":40},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}