This family represents a conserved region approximately 260 residues long within a number of hypothetical proteins of unknown function that seem to be specific to C. elegans. Note that this family contains a number of conserved cysteine and histidine residues.This family corresponds to the Mirage group of putative transposases and family members are relatively close homologs of Transposase_21 ([pfam:PF02992]) proteins (1).
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098031":{"PMID":24464998,"ISBN":null,"volume":"42","issue":"7","year":2014,"title":"The RNase H-like superfamily: new members, comparative structural analysis and evolutionary classification.","URL":null,"raw_pages":"4160-79","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res","authors":["Majorek KA","Dunin-Horkawicz S","Steczkiewicz K","Muszewska A","Nowotny M","Ginalski K","Bujnicki JM."],"DOI_URL":null}},"set_info":{"accession":"CL0219","name":"RNase_H"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":15,"interactions":0,"matches":394,"pathways":0,"proteins":394,"proteomes":68,"sets":1,"structural_models":{"alphafold":359},"structures":0,"taxa":273},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":355},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}