{"metadata":{"accession":"PF06840","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"Programmed cell death protein 10, C-terminal","short":"PDC10_C"},"description":[{"text":"<p>Programmed cell death 10 protein (PDCD10/CCM3) is part of the CCM complex and is required for neuronal migration [[cite:PUB00076417]]. Outside of this complex, it is crucial in vascularization and in angiogenesis as it functions in vessel permeability and stability [[cite:PUB00096889]]. PDCD10/CCM3 contains an N-terminal dimerisation domain and a C-terminal focal adhesion targeting-homology (FAT-H) domain (represented in this entry) [[cite:PUB00076418]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00096889":{"PMID":26490252,"ISBN":null,"volume":"15","issue":null,"year":2015,"title":"Downregulation of programmed cell death 10 is associated with tumor cell proliferation, hyperangiogenesis and peritumoral edema in human glioblastoma.","URL":null,"raw_pages":"759","medline_journal":"BMC Cancer","ISO_journal":"BMC Cancer","authors":["Lambertz N","El Hindy N","Kreitschmann-Andermahr I","Stein KP","Dammann P","Oezkan N","Mueller O","Sure U","Zhu Y."],"DOI_URL":null},"PUB00076418":{"PMID":24481819,"ISBN":null,"volume":"127","issue":"Pt 4","year":2014,"title":"Cerebral cavernous malformation proteins at a glance.","URL":null,"raw_pages":"701-7","medline_journal":"J Cell Sci","ISO_journal":"J. Cell. Sci.","authors":["Draheim KM","Fisher OS","Boggon TJ","Calderwood DA."],"DOI_URL":"http://dx.doi.org/10.1242/jcs.138388"},"PUB00076417":{"PMID":24595293,"ISBN":null,"volume":"141","issue":"6","year":2014,"title":"Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration.","URL":null,"raw_pages":"1404-15","medline_journal":"Development","ISO_journal":"Development","authors":["Louvi A","Nishimura S","Gunel M."],"DOI_URL":"http://dx.doi.org/10.1242/dev.093526"}},"set_info":{"accession":"CL0705","name":"VBS-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":22,"interactions":0,"matches":1841,"pathways":0,"proteins":1839,"proteomes":1219,"sets":1,"structural_models":{"alphafold":1642},"structures":10,"taxa":4069},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":18,"alignment:full":1383},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}