{"metadata":{"accession":"PF06824","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008313","hierarchy":null,"name":{"name":"Metal-independent alpha-mannosidase (GH125)","short":"Glyco_hydro_125"},"description":[{"text":"<p>This family, which contains bacterial and fungal glycoside hydrolases, is also known as GH125. They function as metal-independent alpha-mannosidases, with specificity for alpha-1,6-linked non-reducing terminal mannose residues[[cite:PUB00055745]]. Structurally this family is part of the 6 hairpin glycosidase superfamily.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00055745":{"PMID":21388958,"ISBN":null,"volume":"286","issue":"17","year":2011,"title":"Analysis of a new family of widely distributed metal-independent alpha-mannosidases provides unique insight into the processing of N-linked glycans.","URL":null,"raw_pages":"15586-96","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Gregg KJ","Zandberg WF","Hehemann JH","Whitworth GE","Deng L","Vocadlo DJ","Boraston AB."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M111.223172"}},"set_info":{"accession":"CL0059","name":"6_Hairpin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":59,"interactions":0,"matches":5479,"pathways":0,"proteins":5382,"proteomes":3430,"sets":1,"structural_models":{"alphafold":3901},"structures":12,"taxa":5989},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":176,"alignment:full":3605},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3qry","name":"Analysis of a new family of widely distributed metal-independent alpha mannosidases provides unique insight into the processing of N-linked glycans, Streptococcus pneumoniae SP_2144 1-deoxymannojirimycin complex"}}}