{"metadata":{"accession":"PF06821","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010662","hierarchy":null,"name":{"name":"Serine hydrolase","short":"Ser_hydrolase"},"description":[{"text":"<p>Members of this family have serine hydrolase activity. They contain a conserved serine hydrolase motif, GXSXG/A, where the serine is a putative nucleophile [[cite:PUB00070832]]. This family has an alpha-beta hydrolase fold [[cite:PUB00019449],[cite:PUB00049125]]. Eukaryotic members of this family have a conserved LXCXE motif, which binds to retinoblastomas. This motif is absent from prokaryotic members of this family [[cite:PUB00049125]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00070832":{"PMID":20080647,"ISBN":null,"volume":"107","issue":"5","year":2010,"title":"RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia.","URL":null,"raw_pages":"2189-94","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Shields DJ","Niessen S","Murphy EA","Mielgo A","Desgrosellier JS","Lau SK","Barnes LA","Lesperance J","Bouvet M","Tarin D","Cravatt BF","Cheresh DA."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0911646107"},"PUB00019449":{"PMID":15159570,"ISBN":null,"volume":"60","issue":"Pt 6","year":2004,"title":"Harvesting the high-hanging fruit: the structure of the YdeN gene product from Bacillus subtilis at 1.8 angstroms resolution.","URL":null,"raw_pages":"1101-7","medline_journal":"Acta Crystallogr D Biol Crystallogr","ISO_journal":"Acta Crystallogr. D Biol. Crystallogr.","authors":["Janda I","Devedjiev Y","Cooper D","Chruszcz M","Derewenda U","Gabrys A","Minor W","Joachimiak A","Derewenda ZS."],"DOI_URL":"http://dx.doi.org/10.1107/S0907444904007188"},"PUB00049125":{"PMID":19004028,"ISBN":null,"volume":"74","issue":"2","year":2009,"title":"Crystal structure of human retinoblastoma binding protein 9.","URL":null,"raw_pages":"526-9","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Vorobiev SM","Su M","Seetharaman J","Huang YJ","Chen CX","Maglaqui M","Janjua H","Proudfoot M","Yakunin A","Xiao R","Acton TB","Montelione GT","Tong L."],"DOI_URL":"http://dx.doi.org/10.1002/prot.22278"}},"set_info":{"accession":"CL0028","name":"AB_hydrolase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":33,"interactions":0,"matches":7519,"pathways":0,"proteins":7512,"proteomes":5469,"sets":1,"structural_models":{"alphafold":4651},"structures":5,"taxa":8376},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":16,"alignment:full":3322},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1uxo","name":"The crystal structure of the ydeN gene product from B. subtilis"}}}