{"metadata":{"accession":"PF06777","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010643","hierarchy":null,"name":{"name":"Helical and beta-bridge domain","short":"HBB"},"description":[{"text":"<p>HBB is the domain on DEAD-box eukaryotic DNA repair helicases ([ec:3.6.1.-]) that appears to be a unique fold. It's conformation is of alpha-helices 12-16 plus a short beta-bridge to the FeS-cluster domain at the N-terminal. The full-length XPD protein verifies the presence of damage to DNA and allows DNA repair to proceed. XPD is an assembly of several domains to form a doughnut-shaped molecule that is able to separate two DNA strands and scan the DNA for damage. HBB helps to form the overall DNA-clamping architecture [[cite:PUB00049879]].  This family represents a conserved region within a number of eukaryotic DNA repair helicases ([ec:3.6.1.-]).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00049879":{"PMID":18578568,"ISBN":null,"volume":"6","issue":"6","year":2008,"title":"Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD.","URL":null,"raw_pages":"e149","medline_journal":"PLoS Biol","ISO_journal":"PLoS Biol.","authors":["Wolski SC","Kuper J","Hanzelmann P","Truglio JJ","Croteau DL","Van Houten B","Kisker C."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pbio.0060149"}},"set_info":{"accession":"CL0823","name":"XPD_ARCH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":86,"interactions":0,"matches":3984,"pathways":0,"proteins":3960,"proteomes":3064,"sets":1,"structural_models":{"alphafold":3353},"structures":85,"taxa":8095},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":35,"alignment:full":2989},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}