{"metadata":{"accession":"PF06762","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR057434","hierarchy":null,"name":{"name":"Lipase maturation factor transmembrane domain","short":"LMF1"},"description":[{"text":"<p>This entry represents a domain found in the transmembrane proteins lipase maturation factor, LMF1 and LMF2. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states [[cite:PUB00057509]]. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway [[cite:PUB00057511],[cite:PUB00098585]]. This domain is predicted as a transmembrane. It contains two structural repeats each of which is similar to members of the DoxD-like superfamily.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00057511":{"PMID":20543905,"ISBN":null,"volume":"5","issue":"1","year":2010,"title":"Mechanisms of lipase maturation.","URL":null,"raw_pages":"71-85","medline_journal":"Clin Lipidol","ISO_journal":"Clin Lipidol","authors":["Doolittle MH","Peterfy M."],"DOI_URL":null},"PUB00057509":{"PMID":17994020,"ISBN":null,"volume":"39","issue":"12","year":2007,"title":"Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia.","URL":null,"raw_pages":"1483-7","medline_journal":"Nat Genet","ISO_journal":"Nat. Genet.","authors":["Peterfy M","Ben-Zeev O","Mao HZ","Weissglas-Volkov D","Aouizerat BE","Pullinger CR","Frost PH","Kane JP","Malloy MJ","Reue K","Pajukanta P","Doolittle MH."],"DOI_URL":"http://dx.doi.org/10.1038/ng.2007.24"},"PUB00098585":{"PMID":24909692,"ISBN":null,"volume":"450","issue":"1","year":2014,"title":"Purification, cellular levels, and functional domains of lipase maturation factor 1.","URL":null,"raw_pages":"423-8","medline_journal":"Biochem Biophys Res Commun","ISO_journal":"Biochem Biophys Res Commun","authors":["Babilonia-Rosa MA","Neher SB."],"DOI_URL":null}},"set_info":{"accession":"CL0131","name":"DoxD-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":66,"interactions":0,"matches":4909,"pathways":0,"proteins":4751,"proteomes":2921,"sets":1,"structural_models":{"alphafold":3452},"structures":0,"taxa":6050},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":35,"alignment:full":3255},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}