This domain formerly known as DUF1220 or NBPF domain has been renamed as the Olduvai domain. It is found highly duplicated in the human lineage.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Olduvai_domain","extract":"The Olduvai domain, known until 2018 as DUF1220 and the NBPF repeat, is a protein domain that shows a striking human lineage-specific (HLS) increase in copy number and appears to be involved in human brain evolution. The protein domain has also been linked to several neurogenetic disorders such as schizophrenia and increased severity of autism. In 2018, it was named by its discoverers after Olduvai Gorge in Tanzania, one of the most important archaeological sites for early humans, to reflect data indicating its role in human brain size and evolution.
","thumbnail":null}],"literature":{"PUB00053867":{"PMID":19850849,"ISBN":null,"volume":null,"issue":null,"year":2009,"title":"DUF1220 Domains, Cognitive Disease, and Human Brain Evolution.","URL":null,"raw_pages":null,"medline_journal":"Cold Spring Harb Symp Quant Biol","ISO_journal":"Cold Spring Harb. Symp. Quant. Biol.","authors":["Dumas L","Sikela JM."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":36,"interactions":0,"matches":3063,"pathways":0,"proteins":1373,"proteomes":120,"sets":0,"structural_models":{"alphafold":506},"structures":0,"taxa":406},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":15,"alignment:full":2058},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}