{"metadata":{"accession":"PF06744","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010623","hierarchy":null,"name":{"name":"Type VI secretion protein IcmF C2-like domain","short":"IcmF_C"},"description":[{"text":"<p>IcmF_C family represents a conserved region situated towards the C-terminal end of IcmF-like proteins. It was thought to be involved in Vibrio cholerae cell surface reorganisation that results in increased adherence to epithelial cells leading to an increased conjugation frequency [[cite:PUB00012816]]. IcmF as a whole interacts with DotU whereby these bind tightly and form the docking area of the T6SS within the inner membrane.  The exact function of this domain is not clear [[cite:PUB00075434]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075434":{"PMID":24381728,"ISBN":null,"volume":"5","issue":null,"year":2013,"title":"The rise of the Type VI secretion system.","URL":null,"raw_pages":"52","medline_journal":"F1000Prime Rep","ISO_journal":"F1000Prime Rep","authors":["Filloux A."],"DOI_URL":"http://dx.doi.org/10.12703/P5-52"},"PUB00012816":{"PMID":12127983,"ISBN":null,"volume":"295","issue":"4","year":2002,"title":"Involvement of in vivo induced icmF gene of Vibrio cholerae in motility, adherence to epithelial cells, and conjugation frequency.","URL":null,"raw_pages":"922-8","medline_journal":"Biochem Biophys Res Commun","ISO_journal":"Biochem. Biophys. Res. Commun.","authors":["Das S","Chakrabortty A","Banerjee R","Chaudhuri K."],"DOI_URL":"http://dx.doi.org/10.1016/S0006-291X(02)00782-9"}},"set_info":{"accession":"CL0154","name":"C2"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":20,"interactions":0,"matches":4309,"pathways":0,"proteins":4309,"proteomes":2895,"sets":1,"structural_models":{"alphafold":2258},"structures":5,"taxa":4029},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":81,"alignment:full":1404},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}