{"metadata":{"accession":"PF06740","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009603","hierarchy":null,"name":{"name":"Microtubule associated protein Futsch","short":"MAP_Futsch"},"description":[{"text":"<p>The Drosophila protein Futsch has homology to MAP1B and controls synaptic growth at the Drosophila neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. Ftusch protein colocalises with microtubules and identifies cytoskeletal loops that traverse the lateral margin of select synaptic boutons. Futsch mutations disrupt synaptic microtubule organisation. The N- and C-terminal domains of Futsch are homologous to the vertebrate MAP1B microtubule-associated protein. The central domain of Futsch is highly repetitive and it is represented in this entry [[cite:PUB00059957]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00078101":{"PMID":10839355,"ISBN":null,"volume":"26","issue":"2","year":2000,"title":"Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development.","URL":null,"raw_pages":"357-70","medline_journal":"Neuron","ISO_journal":"Neuron","authors":["Hummel T","Krukkert K","Roos J","Davis G","Klambt C."],"DOI_URL":"http://dx.doi.org/10.1016/S0896-6273(00)81169-1"},"PUB00059957":{"PMID":10839356,"ISBN":null,"volume":"26","issue":"2","year":2000,"title":"Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth.","URL":null,"raw_pages":"371-82","medline_journal":"Neuron","ISO_journal":"Neuron","authors":["Roos J","Hummel T","Ng N","Klambt C","Davis GW."],"DOI_URL":"http://dx.doi.org/10.1016/S0896-6273(00)81170-8"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":32,"interactions":0,"matches":1209,"pathways":0,"proteins":44,"proteomes":33,"sets":0,"structural_models":{"alphafold":3},"structures":0,"taxa":156},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":50,"alignment:full":783},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}