{"metadata":{"accession":"PF06690","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009573","hierarchy":null,"name":{"name":"FeGP cofactor biosynthesis protein, methyltransferase HcgC","short":"HcgC"},"description":[{"text":"<p>The iron guanylylpyridinol (FeGP) cofactor biosynthesis enzymes are encoded in a cluster of at least seven conserved genes (hcgA-G). This family represents the (SAM)-dependent methyltransferase HgcC [[cite:PUB00098593],[cite:PUB00098592]], which covalently attaches the methyl group at the 3-position of the pyridinol ring. It is predominantly found as a monomer in solution, composed of a Rossmann-like coenzyme-binding-domain consisting of six parallel and one peripheral antiparallel strand flanked by six alpha-helices and a smaller alpha/beta domain [[cite:PUB00098593]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00098593":{"PMID":27391308,"ISBN":null,"volume":"55","issue":"33","year":2016,"title":"Identification of HcgC as a SAM-Dependent Pyridinol Methyltransferase in [Fe]-Hydrogenase Cofactor Biosynthesis.","URL":null,"raw_pages":"9648-51","medline_journal":"Angew Chem Int Ed Engl","ISO_journal":"Angew Chem Int Ed Engl","authors":["Fujishiro T","Bai L","Xu T","Xie X","Schick M","Kahnt J","Rother M","Hu X","Ermler U","Shima S."],"DOI_URL":null},"PUB00098592":{"PMID":28682478,"ISBN":null,"volume":"56","issue":"36","year":2017,"title":"A Water-Bridged H-Bonding Network Contributes to the Catalysis of the SAM-Dependent C-Methyltransferase HcgC.","URL":null,"raw_pages":"10806-10809","medline_journal":"Angew Chem Int Ed Engl","ISO_journal":"Angew Chem Int Ed Engl","authors":["Bai L","Wagner T","Xu T","Hu X","Ermler U","Shima S."],"DOI_URL":null}},"set_info":{"accession":"CL0063","name":"NADP_Rossmann"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":49,"pathways":0,"proteins":49,"proteomes":45,"sets":1,"structural_models":{"alphafold":44},"structures":9,"taxa":114},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":10,"alignment:full":22},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5d4v","name":"HcgC with SAH and a guanylylpyridinol (GP) derivative"}}}