{"metadata":{"accession":"PF06682","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009567","hierarchy":null,"name":{"name":"SOCE-associated regulatory factor of calcium homoeostasis","short":"SARAF"},"description":[{"text":"<p>SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain.  STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling [[cite:PUB00075537]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075537":{"PMID":22464749,"ISBN":null,"volume":"149","issue":"2","year":2012,"title":"SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling.","URL":null,"raw_pages":"425-38","medline_journal":"Cell","ISO_journal":"Cell","authors":["Palty R","Raveh A","Kaminsky I","Meller R","Reuveny E."],"DOI_URL":"http://dx.doi.org/10.1016/j.cell.2012.01.055"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":44,"interactions":0,"matches":2789,"pathways":0,"proteins":2681,"proteomes":2228,"sets":0,"structural_models":{"alphafold":2297},"structures":3,"taxa":5903},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":42,"alignment:full":2231},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6o2u","name":"Crystal structure of the SARAF luminal domain"}}}