{"metadata":{"accession":"PF06672","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009558","hierarchy":null,"name":{"name":"MagC peptidoglycan-binding NlpC/P60-like protein","short":"MagC"},"description":[{"text":"<p>This family represents MagC and related proteins that adopt an NlpC/P60-like fold but are catalytically inactive [[cite:PUB00164055]]. The structure consists of a six-stranded beta-sheet and five alpha-helices with a Cys-His-His catalytic triad characteristic of NlpC/P60 peptidases. However, a conserved tryptophan residue distorts the active site conformation, rendering these proteins unable to cleave peptidoglycan while retaining the ability to bind it [[cite:PUB00164055]]. In Pseudomonas aeruginosa, MagC is part of a type II alpha-2- macroglobulin complex encoded by the magABCDEF operon, where it directly interacts with the macroglobulin MagD [[cite:PUB00164055]]. These proteins are proposed to anchor the macroglobulin complex to the peptidoglycan layer in the bacterial periplasm [[cite:PUB00164055]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00164055":{"PMID":34169548,"ISBN":null,"volume":"45","issue":"3","year":2022,"title":"Root angle in maize influences nitrogen capture and is regulated by calcineurin B-like protein (CBL)-interacting serine/threonine-protein kinase 15 (ZmCIPK15).","URL":null,"raw_pages":"837-853","medline_journal":"Plant Cell Environ","ISO_journal":"Plant Cell Environ","authors":["Schneider HM","Lor VSN","Hanlon MT","Perkins A","Kaeppler SM","Borkar AN","Bhosale R","Zhang X","Rodriguez J","Bucksch A","Bennett MJ","Brown KM","Lynch JP."],"DOI_URL":"https://doi.org/10.1111/pce.14135"}},"set_info":{"accession":"CL0125","name":"Peptidase_CA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":476,"pathways":0,"proteins":436,"proteomes":430,"sets":1,"structural_models":{"alphafold":252},"structures":1,"taxa":664},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":152},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7bk8","name":"X-ray crystal structure of Pseudomonas aeruginosa MagC"}}}