This is a family of probable membrane tight junction, Claudin-like, proteins.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Claudin","extract":"Claudins are a family of proteins which, along with occludin, are the most important components of the tight junctions. Tight junctions establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium. They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm.
","thumbnail":null},{"title":"Tight_junction","extract":"Tight junctions, also known as occluding junctions or zonulae occludentes, are multiprotein junctional complexes between epithelial cells, sealing and preventing leakage of solutes and water. They also play a critical role maintaining the structure and permeability of endothelial cells. Tight junctions may also serve as leaky pathways by forming selective channels for small cations, anions, or water. The corresponding junctions that occur in invertebrates are septate junctions.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0375","name":"Transporter"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":15,"interactions":0,"matches":449,"pathways":0,"proteins":442,"proteomes":122,"sets":1,"structural_models":{"alphafold":423},"structures":0,"taxa":493},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":24,"alignment:full":384},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}