{"metadata":{"accession":"PF06603","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010570","hierarchy":null,"name":{"name":"UpxZ family of transcription anti-terminator antagonists","short":"UpxZ"},"description":[{"text":"<p>The UpxZ family of proteins acts to inhibit transcription of heterologous capsular polysaccharide loci in Bacteroides species by interfering with the action of the UpxY family of transcription anti-terminators. As antagonists of polysaccharide locus-specific UpxY transcription anti-terminators, the UpxZ proteins exert a hierarchical level of regulation, insuring that only one of the multiple phase-variable capsular polysaccharide loci per cell characteristic of this genus is transcribed at a time.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00062144":{"PMID":20547868,"ISBN":null,"volume":"107","issue":"26","year":2010,"title":"Trans locus inhibitors limit concomitant polysaccharide synthesis in the human gut symbiont Bacteroides fragilis.","URL":null,"raw_pages":"11976-80","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Chatzidaki-Livanis M","Weinacht KG","Comstock LE."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.1005039107"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":156,"pathways":0,"proteins":156,"proteomes":28,"sets":0,"structural_models":{"alphafold":125},"structures":1,"taxa":49},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":40,"alignment:full":80},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4epz","name":"Crystal structure of a transcription anti-terminator antagonist UpxZ (BACUNI_04315) from Bacteroides uniformis ATCC 8492 at 1.68 A resolution"}}}