{"metadata":{"accession":"PF06577","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008325","hierarchy":null,"name":{"name":"Envelope integrity protein A","short":"EipA"},"description":[{"text":"<p>This family includes envelope integrity protein A (EipA), a protein required for B. abortus envelope stress resistance and infection. It's gene expression is directly activated by CtrA which binds to the promoter region. eipA encodes a soluble periplasmic protein that adopts an unusual eight-stranded beta-barrel fold [[cite:PUB00091721]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00091721":{"PMID":30536925,"ISBN":null,"volume":null,"issue":null,"year":2018,"title":"Periplasmic protein EipA determines envelope stress resistance and virulence in Brucella abortus.","URL":null,"raw_pages":null,"medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Herrou J","Willett JW","Fiebig A","Varesio LM","Czyz DM","Cheng JX","Ultee E","Briegel A","Bigelow L","Babnigg G","Kim Y","Crosson S."],"DOI_URL":"https://doi.org/10.1111/mmi.14178"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":1554,"pathways":0,"proteins":1554,"proteomes":1534,"sets":0,"structural_models":{"alphafold":1006},"structures":1,"taxa":2053},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":30,"alignment:full":884},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5uc0","name":"Crystal Structure of Beta-barrel-like, Uncharacterized Protein of COG5400 from Brucella abortus"}}}