This family consists of several hypothetical archaeal and bacterial proteins of unknown function, including [swissprot:O67778] from Aquifex aeolicus. The structure of this protein has been solved [[cite:PUB00100674]] but its function remains unknown. Members of this family seem to have an acyl-CoA N-acyltransferase topology.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00100674":{"PMID":26243886,"ISBN":null,"volume":"28","issue":"11","year":2015,"title":"On the predictability of the orientation of protein domains joined by a spanning alpha-helical linker.","URL":null,"raw_pages":"491-9","medline_journal":"Protein Eng Des Sel","ISO_journal":"Protein Eng Des Sel","authors":["Lai YT","Jiang L","Chen W","Yeates TO."],"DOI_URL":null}},"set_info":{"accession":"CL0257","name":"Acetyltrans"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":63,"pathways":0,"proteins":63,"proteomes":63,"sets":1,"structural_models":{"alphafold":62},"structures":4,"taxa":150},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":39},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}