{"metadata":{"accession":"PF06550","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010545","hierarchy":null,"name":{"name":"Signal-peptide peptidase, presenilin aspartyl protease","short":"SPP"},"description":[{"text":"<p>SPP is a family of signal-peptide aspartyl proteases. The family carries the characteristic catalytic aspartate GXGD motif, and members are integral membrane peptidases of the presenilin-type with nine transmembrane regions. UniProtKB:Q18K19 is part of the TCDB family 1.A.54.3.4, the presenilin er Ca(2+) leak channel (presenilin).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00065205":{"PMID":23254940,"ISBN":null,"volume":"493","issue":"7430","year":2013,"title":"Structure of a presenilin family intramembrane aspartate protease.","URL":null,"raw_pages":"56-61","medline_journal":"Nature","ISO_journal":"Nature","authors":["Li X","Dang S","Yan C","Gong X","Wang J","Shi Y."],"DOI_URL":"http://dx.doi.org/10.1038/nature11801"}},"set_info":{"accession":"CL0130","name":"Peptidase_AD"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":449,"pathways":0,"proteins":425,"proteomes":405,"sets":1,"structural_models":{"alphafold":397},"structures":4,"taxa":710},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":209},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}