{"metadata":{"accession":"PF06544","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010541","hierarchy":null,"name":{"name":"Small nuclear ribonucleoprotein Prp3, C-terminal domain","short":"Prp3_C"},"description":[{"text":"<p>This domain is found at the C-terminal end of U4/U6 and U4/U5/U6- small nuclear ribonucleoprotein Prp3, part of the tri-RNA complex that form the spliceosome. Prp3 plays a key role in the recognition of the snRNA duplex. This binding domain, highly conserved among eukaryotes, interacts with the 3' end of U6 snRNA. It adopts a ferredoxin-like fold, showing a five-stranded mixed beta-sheet with three alpha-helices, two of them running parallel to the beta-strands on one side of the sheet and one on the other. This fold is extended with a long beta-hairpin, an extra beta-strand, an helix and a final loop at the C terminus. It is located C-terminal to [pfam:PF08572] [[cite:PUB00100665],[cite:PUB00100667],[cite:PUB00100664],[cite:PUB00100666]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100664":{"PMID":26161500,"ISBN":null,"volume":"4","issue":null,"year":2015,"title":"A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing.","URL":null,"raw_pages":"e07320","medline_journal":"Elife","ISO_journal":"Elife","authors":["Liu S","Mozaffari-Jovin S","Wollenhaupt J","Santos KF","Theuser M","Dunin-Horkawicz S","Fabrizio P","Bujnicki JM","Luhrmann R","Wahl MC."],"DOI_URL":null},"PUB00100666":{"PMID":26743623,"ISBN":null,"volume":"351","issue":"6272","year":2016,"title":"The 3.8 A structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis.","URL":null,"raw_pages":"466-75","medline_journal":"Science","ISO_journal":"Science","authors":["Wan R","Yan C","Bai R","Wang L","Huang M","Wong CC","Shi Y."],"DOI_URL":null},"PUB00100667":{"PMID":26829225,"ISBN":null,"volume":"530","issue":"7590","year":2016,"title":"Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 A resolution.","URL":null,"raw_pages":"298-302","medline_journal":"Nature","ISO_journal":"Nature","authors":["Nguyen THD","Galej WP","Bai XC","Oubridge C","Newman AJ","Scheres SHW","Nagai K."],"DOI_URL":null},"PUB00100665":{"PMID":26912367,"ISBN":null,"volume":"351","issue":"6280","year":2016,"title":"Molecular architecture of the human U4/U6.U5 tri-snRNP.","URL":null,"raw_pages":"1416-20","medline_journal":"Science","ISO_journal":"Science","authors":["Agafonov DE","Kastner B","Dybkov O","Hofele RV","Liu WT","Urlaub H","Luhrmann R","Stark H."],"DOI_URL":null}},"set_info":{"accession":"CL0622","name":"Acylphosphatase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":123,"interactions":0,"matches":7097,"pathways":0,"proteins":7079,"proteomes":3389,"sets":1,"structural_models":{"alphafold":6124},"structures":35,"taxa":8940},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":153,"alignment:full":5551},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4yhv","name":"Yeast Prp3 C-terminal fragment 325-469"}}}