{"metadata":{"accession":"PF06532","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009495","hierarchy":null,"name":{"name":"Negative regulator of sigma F","short":"NrsF"},"description":[{"text":"<p>This family includes CC3252 (NrsF- Negative regulator of sigma F) from Caulobacter crescentus, which is proposed to be an anti-sigma factor. In particular, overexpression of NrsF prevents the induction of the sigF regulon after dichromate stress [[cite:PUB00086036]]. Family members also include the anti-sigma factor OsrA (blr3039) from Bradyrhizobium japonicum, which is involved in sensing reactive oxygen species. There is evidence that OsrA binds an ECF-type sigma factor (EcfF) in vivo. Furthermore, the conserved cysteine residues 129 and 179 of OsrA are shown to be required for normal function [[cite:PUB00109140]]. Family members have 6 predicted transmembrane regions.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00086036":{"PMID":22985357,"ISBN":null,"volume":"12","issue":null,"year":2012,"title":"Extracytoplasmic function (ECF) sigma factor σF is involved in Caulobacter crescentus response to heavy metal stress.","URL":null,"raw_pages":"210","medline_journal":"BMC Microbiol","ISO_journal":"BMC Microbiol.","authors":["Kohler C","Lourenco RF","Avelar GM","Gomes SL."],"DOI_URL":"https://doi.org/10.1186/1471-2180-12-210"},"PUB00109140":{"PMID":22916258,"ISBN":null,"volume":"7","issue":"8","year":2012,"title":"Reactive oxygen species-inducible ECF σ factors of Bradyrhizobium japonicum.","URL":null,"raw_pages":"e43421","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Masloboeva N","Reutimann L","Stiefel P","Follador R","Leimer N","Hennecke H","Mesa S","Fischer HM."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":2052,"pathways":0,"proteins":2051,"proteomes":1684,"sets":0,"structural_models":{"alphafold":1262},"structures":0,"taxa":2411},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":81,"alignment:full":966},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}