This family consists of several hypothetical proteins of unknown function which appear to be found largely in Helicobacter pylori. The structure of HP0721 protein consists of a bundle of four alpha-helices connected by loops and stabilised by hydrophobic interactions. It has been suggested that this protein might represent a novel H. pylori [[cite:PUB00097448]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00097448":{"PMID":21365686,"ISBN":null,"volume":"79","issue":"5","year":2011,"title":"Crystal structure of HP0721, a novel secreted protein from Helicobacter pylori.","URL":null,"raw_pages":"1678-81","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Cioci G","Terradot L","Dian C","Mueller-Dieckmann C","Leonard G."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":156,"pathways":0,"proteins":156,"proteomes":109,"sets":0,"structural_models":{"alphafold":119},"structures":1,"taxa":180},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":62},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2xrh","name":"Crystal structure of the truncated form of HP0721"}}}