{"metadata":{"accession":"PF06500","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010520","hierarchy":null,"name":{"name":"Esterase FrsA-like","short":"FrsA-like"},"description":[{"text":"<p>The FrsA-like family includes FrsA, an esterase found to have the alpha/beta-hydrolase fold [[cite:PUB00094022],[cite:PUB00094021],[cite:PUB00058796]]. t also includes the hydrolytic polyketide shortening protein Ayg1 from fungi [[cite:PUB00080691]], 2,6-dihydropseudooxynicotine hydrolase from Paenarthrobacter nicotinovorans [[cite:PUB00041915]] and Fus2 from Gibberella species [[cite:PUB00082317]]. The enzyme 2,6-dihydroxy-pseudo-oxynicotine hydrolase is involved in the nicotine-degradation pathway of Arthrobacter nicotinovorans [[cite:PUB00041915]]. Fus2 is part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C. Fus2 catalyses closure of the 2-pyrrolidone ring of the intermediate 20-hydroxy-prefusarin to form another intermediate, 20-hydroxy-fusarin, which is then oxidized by Fus8 [[cite:PUB00082317]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00041915":{"PMID":17275835,"ISBN":null,"volume":"367","issue":"2","year":2007,"title":"Structure and action of a C-C bond cleaving alpha/beta-hydrolase involved in nicotine degradation.","URL":null,"raw_pages":"409-18","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Schleberger C","Sachelaru P","Brandsch R","Schulz GE."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2006.12.068"},"PUB00094021":{"PMID":23452154,"ISBN":null,"volume":"52","issue":"11","year":2013,"title":"Computational, structural, and kinetic evidence that Vibrio vulnificus FrsA is not a cofactor-independent pyruvate decarboxylase.","URL":null,"raw_pages":"1842-4","medline_journal":"Biochemistry","ISO_journal":"Biochemistry","authors":["Kellett WF","Brunk E","Desai BJ","Fedorov AA","Almo SC","Gerlt JA","Rothlisberger U","Richards NG."],"DOI_URL":null},"PUB00058796":{"PMID":21623357,"ISBN":null,"volume":"7","issue":"7","year":2011,"title":"FrsA functions as a cofactor-independent decarboxylase to control metabolic flux.","URL":null,"raw_pages":"434-6","medline_journal":"Nat Chem Biol","ISO_journal":"Nat. Chem. Biol.","authors":["Lee KJ","Jeong CS","An YJ","Lee HJ","Park SJ","Seok YJ","Kim P","Lee JH","Lee KH","Cha SS."],"DOI_URL":"http://dx.doi.org/10.1038/nchembio.589"},"PUB00094022":{"PMID":30951551,"ISBN":null,"volume":"14","issue":"4","year":2019,"title":"Purification and biochemical characterization of FrsA protein from Vibrio vulnificus as an esterase.","URL":null,"raw_pages":"e0215084","medline_journal":"PLoS One","ISO_journal":"PLoS ONE","authors":["Wang X","Li ZM","Li Q","Shi M","Bao L","Xu D","Li Z."],"DOI_URL":null},"PUB00082317":{"PMID":23932525,"ISBN":null,"volume":"20","issue":"8","year":2013,"title":"Genetic manipulation of the Fusarium fujikuroi fusarin gene cluster yields insight into the complex regulation and fusarin biosynthetic pathway.","URL":null,"raw_pages":"1055-66","medline_journal":"Chem Biol","ISO_journal":"Chem. Biol.","authors":["Niehaus EM","Kleigrewe K","Wiemann P","Studt L","Sieber CM","Connolly LR","Freitag M","Guldener U","Tudzynski B","Humpf HU."],"DOI_URL":"http://dx.doi.org/10.1016/j.chembiol.2013.07.004"},"PUB00080691":{"PMID":15310761,"ISBN":null,"volume":"279","issue":"43","year":2004,"title":"Hydrolytic polyketide shortening by ayg1p, a novel enzyme involved in fungal melanin biosynthesis.","URL":null,"raw_pages":"44613-20","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Fujii I","Yasuoka Y","Tsai HF","Chang YC","Kwon-Chung KJ","Ebizuka Y."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M406758200"}},"set_info":{"accession":"CL0028","name":"AB_hydrolase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":25,"interactions":0,"matches":3495,"pathways":0,"proteins":3494,"proteomes":2667,"sets":1,"structural_models":{"alphafold":2440},"structures":15,"taxa":4571},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":1927},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4i4c","name":"Crystal structure of the protein frsA complexed with unknown ligand"}}}