{"metadata":{"accession":"PF06461","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009462","hierarchy":null,"name":{"name":"CHD subfamily II, SANT-like domain","short":"CHDII_SANT-like"},"description":[{"text":"<p>CHD proteins (name derived from the presence of a Chromodomain, SWI2/SNF2 ATPase/Helicase and a motif with sequence similarity to a DNA)binding domain) are ATP-dependent chromatin remodelers found in plant and animals. In eukaryotes, there are three subfamilies, I, II and III. This domain is found in members of subfamily II which play a role in repression of genes involved in developmental regulation, including Mi-2 from Drosophila melanogaster, CHD3/4/5 from animals and PICKLE (a CHD3/4-related protein) from Arabidopsis. Sequence analysis revealed that this domain has a considerable similarity to SANT domains suggesting that it fold into this type of domain and it is integral to the DNA binding domain of CHD remodelers in subfamily II [[cite:PUB00098174]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00098174":{"PMID":23128324,"ISBN":null,"volume":"1829","issue":"2","year":2013,"title":"PICKLE is a CHD subfamily II ATP-dependent chromatin remodeling factor.","URL":null,"raw_pages":"199-210","medline_journal":"Biochim Biophys Acta","ISO_journal":"Biochim Biophys Acta","authors":["Ho KK","Zhang H","Golden BL","Ogas J."],"DOI_URL":null}},"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":194,"interactions":0,"matches":6800,"pathways":0,"proteins":6755,"proteomes":1593,"sets":1,"structural_models":{"alphafold":495},"structures":3,"taxa":5027},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":4990},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}