{"metadata":{"accession":"PF06454","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009457","hierarchy":null,"name":{"name":"THH1/TOM1/TOM3 domain","short":"THH1_TOM1-3_dom"},"description":[{"text":"<p>This domain is found in plant proteins including THH1/TOM1/TOM3 from Arabidopsis. TOM1 and TOM3 are transmembrane proteins necessary for the efficient multiplication of tobamoviruses [[cite:PUB00090719]]. THH1 supports tobamovirus multiplication, but to a lesser extent than TOM1 and TOM3 [[cite:PUB00090720]]. Members containing this domain are part of the GPCR superfamily and involved in stress tolerance [[cite:PUB00097749],[cite:PUB00097748]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00097748":{"PMID":31412764,"ISBN":null,"volume":"20","issue":"1","year":2019,"title":"Genome-wide analysis of the cotton G-coupled receptor proteins (GPCR) and functional analysis of GTOM1, a novel cotton GPCR gene under drought and cold stress.","URL":null,"raw_pages":"651","medline_journal":"BMC Genomics","ISO_journal":"BMC Genomics","authors":["Lu P","Magwanga RO","Kirungu JN","Dong Q","Cai X","Zhou Z","Wang X","Xu Y","Hou Y","Peng R","Wang K","Liu F."],"DOI_URL":null},"PUB00097749":{"PMID":29649144,"ISBN":null,"volume":"9","issue":"4","year":2018,"title":"A Novel G-Protein-Coupled Receptors Gene from Upland Cotton Enhances Salt Stress Tolerance in Transgenic Arabidopsis.","URL":null,"raw_pages":null,"medline_journal":"Genes (Basel)","ISO_journal":"Genes (Basel)","authors":["Lu P","Magwanga RO","Lu H","Kirungu JN","Wei Y","Dong Q","Wang X","Cai X","Zhou Z","Wang K","Liu F."],"DOI_URL":null},"PUB00090719":{"PMID":11836427,"ISBN":null,"volume":"76","issue":"5","year":2002,"title":"Complete inhibition of tobamovirus multiplication by simultaneous mutations in two homologous host genes.","URL":null,"raw_pages":"2491-7","medline_journal":"J Virol","ISO_journal":"J. Virol.","authors":["Yamanaka T","Imai T","Satoh R","Kawashima A","Takahashi M","Tomita K","Kubota K","Meshi T","Naito S","Ishikawa M."],"DOI_URL":"https://doi.org/10.1128/jvi.76.5.2491-2497.2002"},"PUB00090720":{"PMID":16847136,"ISBN":null,"volume":"87","issue":"Pt 8","year":2006,"title":"Involvement of THH1, an Arabidopsis thaliana homologue of the TOM1 gene, in tobamovirus multiplication.","URL":null,"raw_pages":"2397-401","medline_journal":"J Gen Virol","ISO_journal":"J. Gen. Virol.","authors":["Fujisaki K","Ravelo GB","Naito S","Ishikawa M."],"DOI_URL":"https://doi.org/10.1099/vir.0.81942-0"}},"set_info":{"accession":"CL0192","name":"GPCR_A"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":76,"interactions":0,"matches":4649,"pathways":0,"proteins":3885,"proteomes":619,"sets":1,"structural_models":{"alphafold":3083},"structures":0,"taxa":1827},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":15,"alignment:full":3011},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}