{"metadata":{"accession":"PF06439","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010496","hierarchy":null,"name":{"name":"3-keto-alpha-glucoside-1,2-lyase-like domain","short":"3keto-disac_hyd"},"description":[{"text":"<p>This family has structural similarity to an endo-1,3-1,4-beta glucanase belonging to glycoside hydrolase family 16. A member containing this domain, BT2157 from B. thetaiotaomicron [[cite:PUB00097337]], was initially described as a 3-keto trehalose hydrolase involved in trehalose degradation [[cite:PUB00097337]]. However, members of this group of proteins, previously known as DUF1080, have been reported to be 3-keto-alpha-glucoside-1,2-lyases and 3-keto-2-hydroxy-glucal hydratases and named AL/BT2 enzymes [[cite:PUB00160473]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00097337":{"PMID":33657378,"ISBN":null,"volume":"34","issue":"9","year":2021,"title":"Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments.","URL":null,"raw_pages":"108789","medline_journal":"Cell Rep","ISO_journal":"Cell Rep","authors":["Liu H","Shiver AL","Price MN","Carlson HK","Trotter VV","Chen Y","Escalante V","Ray J","Hern KE","Petzold CJ","Turnbaugh PJ","Huang KC","Arkin AP","Deutschbauer AM."],"DOI_URL":null},"PUB00160473":{"PMID":38898276,"ISBN":null,"volume":"631","issue":"8019","year":2024,"title":"An alternative broad-specificity pathway for glycan breakdown in bacteria.","URL":null,"raw_pages":"199-206","medline_journal":"Nature","ISO_journal":"Nature","authors":["Nasseri SA","Lazarski AC","Lemmer IL","Zhang CY","Brencher E","Chen HM","Sim L","Panwar D","Betschart L","Worrall LJ","Brumer H","Strynadka NCJ","Withers SG."],"DOI_URL":"https://doi.org/10.1038/s41586-024-07574-y"}},"set_info":{"accession":"CL0004","name":"Concanavalin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":757,"interactions":0,"matches":21475,"pathways":0,"proteins":19525,"proteomes":4164,"sets":1,"structural_models":{"alphafold":12269},"structures":18,"taxa":6169},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":162,"alignment:full":11361},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3imm","name":"Crystal structure of Putative glycosyl hydrolase (YP_001301887.1) from Parabacteroides distasonis ATCC 8503 at 2.00 A resolution"}}}