This family consists of several repeats of 31 residues in length and seems to be exclusive to Moraxella catarrhalis UspA proteins. The UspA1 and UspA2 proteins of Moraxella catarrhalis are structurally related and are exposed on the bacterial cell surface where can function adhesins [[cite:PUB00012385]]. This family is commonly found with the [pfam:PF03895] family.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00012385":{"PMID":10671460,"ISBN":null,"volume":"182","issue":"5","year":2000,"title":"The UspA1 protein and a second type of UspA2 protein mediate adherence of Moraxella catarrhalis to human epithelial cells in vitro.","URL":null,"raw_pages":"1364-73","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Lafontaine ER","Cope LD","Aebi C","Latimer JL","McCracken GH Jr","Hansen EJ."],"DOI_URL":"http://dx.doi.org/10.1128/JB.182.5.1364-1373.2000"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":19,"interactions":0,"matches":171,"pathways":0,"proteins":56,"proteomes":4,"sets":0,"structural_models":{"alphafold":51},"structures":2,"taxa":13},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":3},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}