{"metadata":{"accession":"PF06417","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009445","hierarchy":null,"name":{"name":"ER membrane protein complex subunit 4","short":"EMC4"},"description":[{"text":"<p>This entry includes ER membrane protein complex subunit 4 (EMC4 also known as TMEM85 in mammals) from animals and its orthologue Emc4 from budding yeasts. They inhibit hydrogen peroxide mediated cell death in yeast [[cite:PUB00086405]]. Emc4 is part of the ER membrane complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins [[cite:PUB00067575],[cite:PUB00096682],[cite:PUB00096681]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00086405":{"PMID":18586032,"ISBN":null,"volume":"582","issue":"17","year":2008,"title":"Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast.","URL":null,"raw_pages":"2637-42","medline_journal":"FEBS Lett","ISO_journal":"FEBS Lett.","authors":["Ring G","Khoury CM","Solar AJ","Yang Z","Mandato CA","Greenwood MT."],"DOI_URL":"https://doi.org/10.1016/j.febslet.2008.06.042"},"PUB00096681":{"PMID":32459176,"ISBN":null,"volume":"9","issue":null,"year":2020,"title":"The architecture of EMC reveals a path for membrane protein insertion.","URL":null,"raw_pages":null,"medline_journal":"Elife","ISO_journal":"Elife","authors":["O'Donnell JP","Phillips BP","Yagita Y","Juszkiewicz S","Wagner A","Malinverni D","Keenan RJ","Miller EA","Hegde RS."],"DOI_URL":null},"PUB00067575":{"PMID":23431131,"ISBN":null,"volume":"110","issue":"11","year":2013,"title":"Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex.","URL":null,"raw_pages":"E1055-63","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Richard M","Boulin T","Robert VJ","Richmond JE","Bessereau JL."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.1216154110"},"PUB00096682":{"PMID":32439656,"ISBN":null,"volume":"369","issue":"6502","year":2020,"title":"Structural basis for membrane insertion by the human ER membrane protein complex.","URL":null,"raw_pages":"433-436","medline_journal":"Science","ISO_journal":"Science","authors":["Pleiner T","Tomaleri GP","Januszyk K","Inglis AJ","Hazu M","Voorhees RM."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":81,"interactions":0,"matches":3918,"pathways":0,"proteins":3905,"proteomes":3220,"sets":0,"structural_models":{"alphafold":3351},"structures":12,"taxa":8600},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":97,"alignment:full":2990},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}