{"metadata":{"accession":"PF06382","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024460","hierarchy":null,"name":{"name":"Protamine and protamine like","short":"Protamine_like"},"description":[{"text":"<p>This family consists of several insect proteins including protamine A (ProtA), protamine B (ProtB) and protamine-like protein 99C (Prtl99C) from Drosophila melanogaster. They contain a HMG-box and are involved in chromatin compaction during spermiogenesis [[cite:PUB00083892],[cite:PUB00083890]]. Prtl99C is a sperm chromatin-associated protein that is essential for male fertility [[cite:PUB00083890]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00083890":{"PMID":26673329,"ISBN":null,"volume":"13","issue":"11","year":2015,"title":"Prtl99C Acts Together with Protamines and Safeguards Male Fertility in Drosophila.","URL":null,"raw_pages":"2327-35","medline_journal":"Cell Rep","ISO_journal":"Cell Rep","authors":["Eren-Ghiani Z","Rathke C","Theofel I","Renkawitz-Pohl R."],"DOI_URL":"http://dx.doi.org/10.1016/j.celrep.2015.11.023"},"PUB00083892":{"PMID":15988027,"ISBN":null,"volume":"25","issue":"14","year":2005,"title":"Replacement by Drosophila melanogaster protamines and Mst77F of histones during chromatin condensation in late spermatids and role of sesame in the removal of these proteins from the male pronucleus.","URL":null,"raw_pages":"6165-77","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Jayaramaiah Raja S","Renkawitz-Pohl R."],"DOI_URL":"http://dx.doi.org/10.1128/MCB.25.14.6165-6177.2005"}},"set_info":{"accession":"CL0114","name":"HMG-box"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":8,"interactions":0,"matches":275,"pathways":0,"proteins":239,"proteomes":83,"sets":1,"structural_models":{"alphafold":214},"structures":0,"taxa":372},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":167},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}