This family consists of several phage and bacterial proteins of unknown function. Computational analysis involving sequence, predicted structure and genomic context suggests that these proteins may be endonucleases which function in phage genome segregation, or the repair of double-stranded breaks introduced during either this process or DNA replication [[cite:PUB00020736]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00020736":{"PMID":15972856,"ISBN":null,"volume":"33","issue":"11","year":2005,"title":"Identification of novel restriction endonuclease-like fold families among hypothetical proteins.","URL":null,"raw_pages":"3598-605","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Kinch LN","Ginalski K","Rychlewski L","Grishin NV."],"DOI_URL":"http://dx.doi.org/10.1093/nar/gki676"}},"set_info":{"accession":"CL0236","name":"PDDEXK"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":807,"pathways":0,"proteins":806,"proteomes":720,"sets":1,"structural_models":{"alphafold":393},"structures":0,"taxa":1566},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":450},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}