{"metadata":{"accession":"PF06327","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009398","hierarchy":null,"name":{"name":"Adenylate cyclase, conserved domain","short":"Adcy_cons_dom"},"description":[{"text":"<p>Adenylate cyclase (AC) enzyme uses ATP as its substrate to produce Cyclic AMP (cAMP), a ubiquitous signalling molecule that mediates many cellular processes by activating cAMP- dependent kinases and also inducing protein-protein interactions. Mammalian adenylate cyclase has nine closely related membrane-bound isoforms (AC1-9) showing significant sequence homology and sharing the same overall structure: two hydrophobic transmembrane domains, and two cytoplasmic domains that are responsible for the catalytic activity. These isoforms differ in both their tissue specificity and their regulation [[cite:PUB00034664],[cite:PUB00034665]]. This entry represents a region of unknown function found in many of these isoforms. It is part of the N-terminal cytoplasmic domain but its presence is not necessary for catalytic activity [[cite:PUB00034666]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00034666":{"PMID":9417641,"ISBN":null,"volume":"278","issue":"5345","year":1997,"title":"Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.","URL":null,"raw_pages":"1907-16","medline_journal":"Science","ISO_journal":"Science","authors":["Tesmer JJ","Sunahara RK","Gilman AG","Sprang SR."],"DOI_URL":"http://dx.doi.org/10.1126/science.278.5345.1907"},"PUB00034664":{"PMID":11264454,"ISBN":null,"volume":"41","issue":null,"year":2001,"title":"Regulation and role of adenylyl cyclase isoforms.","URL":null,"raw_pages":"145-74","medline_journal":"Annu Rev Pharmacol Toxicol","ISO_journal":"Annu. Rev. Pharmacol. Toxicol.","authors":["Hanoune J","Defer N."],"DOI_URL":"http://dx.doi.org/10.1146/annurev.pharmtox.41.1.145"},"PUB00034665":{"PMID":12940771,"ISBN":null,"volume":"375","issue":"Pt 3","year":2003,"title":"Regulation and organization of adenylyl cyclases and cAMP.","URL":null,"raw_pages":"517-29","medline_journal":"Biochem J","ISO_journal":"Biochem. J.","authors":["Cooper DM."],"DOI_URL":"http://dx.doi.org/10.1042/BJ20031061"}},"set_info":{"accession":"CL0276","name":"Nucleot_cyclase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":63,"interactions":0,"matches":8592,"pathways":0,"proteins":8560,"proteomes":1178,"sets":1,"structural_models":{"alphafold":6799},"structures":4,"taxa":3902},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":6628},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}