{"metadata":{"accession":"PF06303","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR035087","hierarchy":null,"name":{"name":"MatP N-terminal domain","short":"MatP"},"description":[{"text":"<p>This family, many of whose members are YcbG, organises the macrodomain Ter of the chromosome of bacteria such as E coli. In these bacteria, insulated macrodomains influence the segregation of sister chromatids and the mobility of chromosomal DNA. Organisation of the Terminus region (Ter) into a macrodomain relies on the presence of a 13 bp motif called matS repeated 23 times in the 800-kb-long domain. MatS sites are the main targets in the E. coli chromosome of YcbG or MatP (macrodomain Ter protein). MatP accumulates in the cell as a discrete focus that co-localises with the Ter macrodomain. The effects of MatP inactivation reveal its role as the main organiser of the Ter macrodomain: in the absence of MatP, DNA is less compacted, the mobility of markers is increased, and segregation of the Ter macrodomain occurs early in the cell cycle. A specific organisational system is required in the Terminus region for bacterial chromosome management during the cell cycle. This entry represents the N-terminal domain of MatP.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00053967":{"PMID":18984159,"ISBN":null,"volume":"135","issue":"3","year":2008,"title":"The MatP/matS site-specific system organizes the terminus region of the E. coli chromosome into a macrodomain.","URL":null,"raw_pages":"475-85","medline_journal":"Cell","ISO_journal":"Cell","authors":["Mercier R","Petit MA","Schbath S","Robin S","El Karoui M","Boccard F","Espeli O."],"DOI_URL":"http://dx.doi.org/10.1016/j.cell.2008.08.031"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":896,"pathways":0,"proteins":896,"proteomes":844,"sets":0,"structural_models":{"alphafold":608},"structures":9,"taxa":1220},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":242},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}