{"metadata":{"accession":"PF06257","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009366","hierarchy":null,"name":{"name":"Biofilm formation stimulator VEG","short":"VEG"},"description":[{"text":"<p>VEG is a family that is highly conserved among Gram-positive bacteria. It stimulates biofilm formation through inducing transcription of the tapA-sipW-tasA operon. The products of this operon are resposible for production of the amyloid fibre (TasA) component of the biofilm. Veg or a Veg-induced protein acts as an antirepressor of SinR - part of the major overall biofilm transcriptional control system - to regulate and stimulate biofilm formation. Veg is transcribed at high levels during both exponential growth and sporulation [[cite:PUB00070838],[cite:PUB00070839]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00070838":{"PMID":12761295,"ISBN":null,"volume":"133","issue":"4","year":2003,"title":"Transcriptional, functional and cytochemical analyses of the veg gene in Bacillus subtilis.","URL":null,"raw_pages":"475-83","medline_journal":"J Biochem","ISO_journal":"J. Biochem.","authors":["Fukushima T","Ishikawa S","Yamamoto H","Ogasawara N","Sekiguchi J."],"DOI_URL":"http://dx.doi.org/10.1093/jb/mvg062"},"PUB00070839":{"PMID":23378512,"ISBN":null,"volume":"195","issue":"8","year":2013,"title":"Functional analysis of the protein Veg, which stimulates biofilm formation in Bacillus subtilis.","URL":null,"raw_pages":"1697-705","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Lei Y","Oshima T","Ogasawara N","Ishikawa S."],"DOI_URL":"http://dx.doi.org/10.1128/JB.02201-12"}},"set_info":{"accession":"CL0010","name":"SH3"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":2633,"pathways":0,"proteins":2633,"proteomes":2624,"sets":1,"structural_models":{"alphafold":1775},"structures":1,"taxa":3732},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":76,"alignment:full":1310},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3fb9","name":"The crystal structure of the protein with unknown function from Streptococcus pneumoniae TIGR4"}}}