{"metadata":{"accession":"PF06251","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010425","hierarchy":null,"name":{"name":"Capsule biosynthesis GfcC C-terminal","short":"Caps_syn_GfcC_C"},"description":[{"text":"<p>Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation [[cite:PUB00062058]].  This family plays a role in group 4 capsule biosynthesis [[cite:PUB00066719]].  These proteins have a beta-grasp fold [[cite:PUB00044948]]. Two beta-grasp domains, D2 and D3, are arranged in tandem. There is a C-terminal amphipathic helix which packs against D3. A helical hairpin insert in D2 binds to D3 and constrains its position, a conserved arginine residue at the end of this hairpin is essential for structural integrity [[cite:PUB00099551]]. This is the C-terminal domain which covers D3 and D4 domains [[cite:PUB00099551]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00066719":{"PMID":16030220,"ISBN":null,"volume":"187","issue":"15","year":2005,"title":"Identification of an Escherichia coli operon required for formation of the O-antigen capsule.","URL":null,"raw_pages":"5259-66","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Peleg A","Shifrin Y","Ilan O","Nadler-Yona C","Nov S","Koby S","Baruch K","Altuvia S","Elgrably-Weiss M","Abe CM","Knutton S","Saper MA","Rosenshine I."],"DOI_URL":"http://dx.doi.org/10.1128/JB.187.15.5259-5266.2005"},"PUB00062058":{"PMID":10200953,"ISBN":null,"volume":"31","issue":"5","year":1999,"title":"Structure, assembly and regulation of expression of capsules in Escherichia coli.","URL":null,"raw_pages":"1307-19","medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Whitfield C","Roberts IS."],"DOI_URL":"http://dx.doi.org/10.1046/j.1365-2958.1999.01276.x"},"PUB00044948":{"PMID":17250770,"ISBN":null,"volume":"2","issue":null,"year":2007,"title":"A novel superfamily containing the beta-grasp fold involved in binding diverse soluble ligands.","URL":null,"raw_pages":"4","medline_journal":"Biol Direct","ISO_journal":"Biol. Direct","authors":["Burroughs AM","Balaji S","Iyer LM","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1186/1745-6150-2-4"},"PUB00099551":{"PMID":21449614,"ISBN":null,"volume":"50","issue":"24","year":2011,"title":"The crystal structure of Escherichia coli group 4 capsule protein GfcC reveals a domain organization resembling that of Wza.","URL":null,"raw_pages":"5465-76","medline_journal":"Biochemistry","ISO_journal":"Biochemistry","authors":["Sathiyamoorthy K","Mills E","Franzmann TM","Rosenshine I","Saper MA."],"DOI_URL":null}},"set_info":{"accession":"CL0072","name":"Ubiquitin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":25,"interactions":0,"matches":941,"pathways":0,"proteins":940,"proteomes":900,"sets":1,"structural_models":{"alphafold":549},"structures":1,"taxa":1356},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":291},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}