{"metadata":{"accession":"PF06242","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010421","hierarchy":null,"name":{"name":"Transcriptional cell cycle regulator TrcR","short":"TrcR"},"description":[{"text":"<p>This family represents a transcriptional cell cycle regulator (TrcR) found in Proteobacteria, mainly Alphaproteobacteria. It has been shown to associate with promoters and coding sequences in vivo in a rifampicin-dependent manner and to interact physically and genetically with RNA polymerase, resulting in the integration of cell cycle and antibiotic stress control with the general transcriptional machinery [[cite:PUB00098048]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00098048":{"PMID":33602809,"ISBN":null,"volume":"118","issue":"8","year":2021,"title":"The DUF1013 protein TrcR tracks with RNA polymerase to control the bacterial cell cycle and protect against antibiotics.","URL":null,"raw_pages":null,"medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Delaby M","Varesio LM","Degeorges L","Crosson S","Viollier PH."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":2557,"pathways":0,"proteins":2557,"proteomes":2549,"sets":0,"structural_models":{"alphafold":1747},"structures":0,"taxa":3635},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":36,"alignment:full":1510},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}