{"metadata":{"accession":"PF06237","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009357","hierarchy":null,"name":{"name":"Solute carrier family 52, riboflavin transporter","short":"SLC52_ribofla_tr"},"description":[{"text":"<p>This family includes animal riboflavin transporters belonging to the Solute carrier family 52 (SLC52). They are plasma membrane proteins that transport vitamin B2 (riboflavin, RF) into cells [[cite:PUB00078059]]. In case of infection by retroviruses, they act as cell receptors to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A) [[cite:PUB00078058]]. These proteins belong to the MFS superfamily [[cite:PUB00103553]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00078059":{"PMID":25284511,"ISBN":null,"volume":"553","issue":"1","year":2014,"title":"Identification and characterization of 5'-flanking region of the human riboflavin transporter 1 gene (SLC52A1).","URL":null,"raw_pages":"49-56","medline_journal":"Gene","ISO_journal":"Gene","authors":["Sabui S","Ghosal A","Said HM."],"DOI_URL":"http://dx.doi.org/10.1016/j.gene.2014.10.001"},"PUB00103553":{"PMID":36164651,"ISBN":null,"volume":"25","issue":"10","year":2022,"title":"A structure and evolutionary-based classification of solute carriers.","URL":null,"raw_pages":"105096","medline_journal":"iScience","ISO_journal":"iScience","authors":["Ferrada E","Superti-Furga G."],"DOI_URL":null},"PUB00078058":{"PMID":19307586,"ISBN":null,"volume":"106","issue":"14","year":2009,"title":"Single-round selection yields a unique retroviral envelope utilizing GPR172A as its host receptor.","URL":null,"raw_pages":"5848-53","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Mazari PM","Linder-Basso D","Sarangi A","Chang Y","Roth MJ."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0809741106"}},"set_info":{"accession":"CL0015","name":"MFS"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":50,"interactions":0,"matches":3419,"pathways":0,"proteins":3128,"proteomes":1243,"sets":1,"structural_models":{"alphafold":2727},"structures":2,"taxa":4015},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":54,"alignment:full":2678},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}