{"metadata":{"accession":"PF06224","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009351","hierarchy":null,"name":{"name":"DNA glycosylase AlkZ-like","short":"AlkZ-like"},"description":[{"text":"<p>This protein family includes DNA glycosylase AlkZ from Streptomyces sahachiroi (also known as Azi36) and similar proteins predominantly found in bacteria. AlkZ is an enzyme that provides self-resistance from azinomycin B (AZB) toxicity by unhooking interstrand cross- links (ICLs). The crystal structure of AlkZ revealed a C-shaped configuration with three tandem winged helix-turn-helix (wHTH) motifs and a positively charged surface that shows residues of great importance for the enzymatic activity [[cite:PUB00100682]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100683":{"PMID":32409837,"ISBN":null,"volume":"48","issue":"13","year":2020,"title":"Escherichia coli YcaQ is a DNA glycosylase that unhooks DNA interstrand crosslinks.","URL":null,"raw_pages":"7005-7017","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res","authors":["Bradley NP","Washburn LA","Christov PP","Watanabe CMH","Eichman BF."],"DOI_URL":null},"PUB00100682":{"PMID":28396405,"ISBN":null,"volume":"114","issue":"17","year":2017,"title":"Structure of a DNA glycosylase that unhooks interstrand cross-links.","URL":null,"raw_pages":"4400-4405","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Mullins EA","Warren GM","Bradley NP","Eichman BF."],"DOI_URL":null}},"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":19,"interactions":0,"matches":17024,"pathways":0,"proteins":16955,"proteomes":7771,"sets":1,"structural_models":{"alphafold":9642},"structures":2,"taxa":10387},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":62,"alignment:full":8023},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}