{"metadata":{"accession":"PF06167","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010384","hierarchy":null,"name":{"name":"Glucose-regulated metallo-peptidase M90","short":"Peptidase_M90"},"description":[{"text":"<p>MtfA (earlier known as YeeI) is a transcription factor A that binds Mlc (make large colonies), itself a repressor of glucose and hence a protein important in regulation of the phosphoenolpyruvate:glucose-phosphotransferase (ptsG) system, the major glucose transporter in E.coli. Mlc is a repressor of ptsG, and MtfA is found to bind and inactivate Mlc with high affinity [[cite:PUB00054592]]. The membrane-bound protein EIICBGlc encoded by the ptsG gene is the major glucose transporter in Escherichia coli. MtfA is found to be a glucose-regulated peptidase [[cite:PUB00066805]], whose activity is regulated by binding to Mlc available in the cytoplasm, which in turn has been released from EIICBGlc during times when no glucose is taken up. A physiologically relevant target for this peptidase is not yet known.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00066805":{"PMID":22178967,"ISBN":null,"volume":"194","issue":"5","year":2012,"title":"Characterization of MtfA, a novel regulatory output signal protein of the glucose-phosphotransferase system in Escherichia coli K-12.","URL":null,"raw_pages":"1024-35","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Gohler AK","Staab A","Gabor E","Homann K","Klang E","Kosfeld A","Muus JE","Wulftange JS","Jahreis K."],"DOI_URL":"http://dx.doi.org/10.1128/JB.06387-11"},"PUB00107876":{"PMID":18359269,"ISBN":null,"volume":"11","issue":"2","year":2008,"title":"The mechanisms of carbon catabolite repression in bacteria.","URL":null,"raw_pages":"87-93","medline_journal":"Curr Opin Microbiol","ISO_journal":"Curr Opin Microbiol","authors":["Deutscher J."],"DOI_URL":null},"PUB00054592":{"PMID":16855233,"ISBN":null,"volume":"188","issue":"15","year":2006,"title":"YeeI, a novel protein involved in modulation of the activity of the glucose-phosphotransferase system in Escherichia coli K-12.","URL":null,"raw_pages":"5439-49","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Becker AK","Zeppenfeld T","Staab A","Seitz S","Boos W","Morita T","Aiba H","Mahr K","Titgemeyer F","Jahreis K."],"DOI_URL":"http://dx.doi.org/10.1128/JB.00219-06"}},"set_info":{"accession":"CL0126","name":"Peptidase_MA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":11,"interactions":0,"matches":4705,"pathways":0,"proteins":4702,"proteomes":4323,"sets":1,"structural_models":{"alphafold":2921},"structures":2,"taxa":6130},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":82,"alignment:full":2055},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3khi","name":"Crystal structure of a Putative Metal-dependent Hydrolase (YP_001336084.1) from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 at 1.95 A resolution"}}}