{"metadata":{"accession":"PF06162","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010381","hierarchy":null,"name":{"name":"Putative pyroglutamyl peptidase PgaPase_1","short":"PgaPase_1"},"description":[{"text":"<p>PgaPase_1 is a family of functionally diverse Caenorhabditis proteins. The family is homologous to the cysteine-peptidases, but lack of a strictly conserved Glu-Cys-His catalytic triad or pGlu binding site implies that it has other functions that could have resulted in a change in reaction-specificity or even of catalytic activity [[cite:PUB00075353]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075353":{"PMID":20537955,"ISBN":null,"volume":"34","issue":"3","year":2010,"title":"The challenge of annotating protein sequences: The tale of eight domains of unknown function in Pfam.","URL":null,"raw_pages":"210-4","medline_journal":"Comput Biol Chem","ISO_journal":"Comput Biol Chem","authors":["Goonesekere NC","Shipely K","O'Connor K."],"DOI_URL":"http://dx.doi.org/10.1016/j.compbiolchem.2010.04.001"}},"set_info":{"accession":"CL0379","name":"PgaPase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":8,"interactions":0,"matches":174,"pathways":0,"proteins":166,"proteomes":112,"sets":1,"structural_models":{"alphafold":157},"structures":0,"taxa":491},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":130},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}