{"metadata":{"accession":"PF06136","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR048351","hierarchy":null,"name":{"name":"SOSEKI protein DIX-like domain","short":"SOK"},"description":[{"text":"<p>This entry represents a group of plant proteins, including protein SOSEKI1-5 from Arabidopsis thaliana and Physcomitrium patens. SOK1-5 integrate apical-basal and radial organismal axes to localise to polar cell edges and contain a DIX oligomerization domain that resembles that in the animal Dishevelled polarity regulator [[cite:PUB00073664],[cite:PUB00096645],[cite:PUB00096647],[cite:PUB00096646]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00096645":{"PMID":18156133,"ISBN":null,"volume":"49","issue":"2","year":2008,"title":"The FLX gene of Arabidopsis is required for FRI-dependent activation of FLC expression.","URL":null,"raw_pages":"191-200","medline_journal":"Plant Cell Physiol","ISO_journal":"Plant Cell Physiol","authors":["Andersson CR","Helliwell CA","Bagnall DJ","Hughes TP","Finnegan EJ","Peacock WJ","Dennis ES."],"DOI_URL":null},"PUB00096647":{"PMID":30737509,"ISBN":null,"volume":"5","issue":"2","year":2019,"title":"A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis.","URL":null,"raw_pages":"160-166","medline_journal":"Nat Plants","ISO_journal":"Nat Plants","authors":["Yoshida S","van der Schuren A","van Dop M","van Galen L","Saiga S","Adibi M","Moller B","Ten Hove CA","Marhavy P","Smith R","Friml J","Weijers D."],"DOI_URL":null},"PUB00096646":{"PMID":32004461,"ISBN":null,"volume":"180","issue":"3","year":2020,"title":"DIX Domain Polymerization Drives Assembly of Plant Cell Polarity Complexes.","URL":null,"raw_pages":"427-439.e12","medline_journal":"Cell","ISO_journal":"Cell","authors":["van Dop M","Fiedler M","Mutte S","de Keijzer J","Olijslager L","Albrecht C","Liao CY","Janson ME","Bienz M","Weijers D."],"DOI_URL":null},"PUB00073664":{"PMID":15186749,"ISBN":null,"volume":"14","issue":"10","year":2004,"title":"A cluster of Arabidopsis genes with a coordinate response to an environmental stimulus.","URL":null,"raw_pages":"911-6","medline_journal":"Curr Biol","ISO_journal":"Curr. Biol.","authors":["Finnegan EJ","Sheldon CC","Jardinaud F","Peacock WJ","Dennis ES."],"DOI_URL":"http://dx.doi.org/10.1016/j.cub.2004.04.045"}},"set_info":{"accession":"CL0072","name":"Ubiquitin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":42,"interactions":0,"matches":3490,"pathways":0,"proteins":3443,"proteomes":377,"sets":1,"structural_models":{"alphafold":2790},"structures":1,"taxa":1031},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":34,"alignment:full":2183},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6rsn","name":"SOSEKI polymerising domain (SOK4 D85A mutant)"}}}