{"metadata":{"accession":"PF06110","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010357","hierarchy":null,"name":{"name":"Thioredoxin domain-containing protein 17-like, thioredoxin domain","short":"TXD17-like_Trx"},"description":[{"text":"<p>This is the thioredoxin domain from in Thioredoxin domain-containing protein 17, also known as TRP14, which is a highly conserved and ubiquitously expressed oxidoreductase involved in controlling of cellular redox signalling pathways [[cite:PUB00032290]]. This domain is also found at the C-terminal of Acireductone dioxygenase (ARD) from Leishmania.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00032290":{"PMID":15355959,"ISBN":null,"volume":"279","issue":"46","year":2004,"title":"Structural basis of cellular redox regulation by human TRP14.","URL":null,"raw_pages":"48120-5","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Woo JR","Kim SJ","Jeong W","Cho YH","Lee SC","Chung YJ","Rhee SG","Ryu SE."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M407079200"}},"set_info":{"accession":"CL0172","name":"Thioredoxin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":65,"interactions":0,"matches":3610,"pathways":0,"proteins":3438,"proteomes":2533,"sets":1,"structural_models":{"alphafold":3009},"structures":6,"taxa":7078},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":2728},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7xq3","name":"Crystal structure of the tetramer of thioredoxin domain containing-protein of Oncomelania hupensis(OhTRP14)"}}}