This family consists of several hypothetical putative membrane proteins from Escherichia coli, Yersinia pestis and Salmonella typhi. Recently, it was proposed that members of this family along with members of DUF3289 ([pfam:PF11692]) should be recognised as a putative toxin-antitoxin pair in which DUF3289 ([pfam:PF11692]) is a homolog of Colicin M and DUF943 acts as its cognate immunity protein [[cite:PUB00154362]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00154362":{"PMID":38658795,"ISBN":null,"volume":null,"issue":null,"year":2024,"title":"Identification of type VI secretion system effector-immunity pairs using structural bioinformatics.","URL":null,"raw_pages":null,"medline_journal":"Mol Syst Biol","ISO_journal":"Mol Syst Biol","authors":["Geller AM","Shalom M","Zlotkin D","Blum N","Levy A."],"DOI_URL":"https://doi.org/10.1038/s44320-024-00035-8"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":553,"pathways":0,"proteins":553,"proteomes":141,"sets":0,"structural_models":{"alphafold":295},"structures":0,"taxa":239},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":10,"alignment:full":153},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}