{"metadata":{"accession":"PF06090","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009286","hierarchy":null,"name":{"name":"Inositol-pentakisphosphate 2-kinase","short":"Ins_P5_2-kin"},"description":[{"text":"<p>This is a family of inositol-pentakisphosphate 2-kinases (EC 2.7.1.158) (also known as inositol 1,3,4,5,6-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase) and InsP5 2-kinase). This enzyme phosphorylates Ins(1,3,4,5,6)P5 to form Ins(1,2,3,4,5,6)P6 (also known as InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, nonhomologous end-joining, endocytosis and ion channel regulation.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00044654":{"PMID":10960485,"ISBN":null,"volume":"275","issue":"47","year":2000,"title":"Biochemical and functional characterization of inositol 1,3,4,5, 6-pentakisphosphate 2-kinases.","URL":null,"raw_pages":"36575-83","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Ives EB","Nichols J","Wente SR","York JD."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M007586200"}},"set_info":{"accession":"CL0016","name":"PKinase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":88,"interactions":0,"matches":4885,"pathways":0,"proteins":4299,"proteomes":3187,"sets":1,"structural_models":{"alphafold":3623},"structures":23,"taxa":8450},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":76,"alignment:full":3688},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}